Plain-English translation of NCT04045665 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Atrial Fibrillation research guide →Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
After bypass heart surgery, some patients develop a condition called atrial fibrillation—an irregular heartbeat that increases stroke risk. This trial compares two treatment approaches: one group will take oral anticoagulants (blood thinners like warfarin or apixaban) along with aspirin, while another group will take aspirin or a similar blood thinner alone. The study will measure whether the medication reduces serious events like stroke while monitoring whether it causes excess bleeding.
Doctors aren't sure whether patients with new irregular heartbeat after bypass surgery benefit more from stronger blood thinning medication or if aspirin alone is safer. This medication is meant to prevent dangerous blood clots and stroke, but it also increases bleeding risk—so researchers need to find the right balance.
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If you join, you will be randomly assigned to either take blood thinner medication plus aspirin or aspirin alone for 90 days. You will have a visit at 90 days and phone check-ins at 30, 60, and 180 days to see how you're doing. The researchers will track whether you experience any serious events like stroke or unusual bleeding during this time.
AI-generated summary from trial data · Jun 29, 2026 · Not medical advice
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