Plain-English translation of NCT04058457 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Parkinson Disease research guide →Researchers at the University of Oxford want to understand how deep brain stimulation—a surgical procedure that uses electrical pulses to help control Parkinson's symptoms—affects breathing. This study will compare breathing function in people receiving different types of brain stimulation surgery, measuring whether the treatment changes how people breathe or sense their own breathing.
Breathing problems are common in Parkinson's disease and can significantly affect quality of life. Doctors don't yet fully understand whether brain stimulation therapy helps, harms, or has no effect on breathing, so this research aims to fill that knowledge gap.
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You will complete breathing tests and questionnaires before your surgery and again after it. After surgery, researchers will test your breathing with the stimulation turned on and off to see if it makes a difference. You'll also wear a small device to track your daily activity and heart rate. The study team will compare brain scan images with your breathing results to understand how the surgery affects these systems.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
United Kingdom
Collaborators
Oxford Brookes University
Enrollment target
~60 participants
Started
April 2021
Primary completion
July 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in March 2025.
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Central contact
Alex Green, FRCS
University of Oxford
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