Plain-English translation of NCT04073966 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This is an observational study that follows 20 patients with newly diagnosed brain cancer spread (brain metastases) who are receiving stereotactic radiosurgery (a focused radiation treatment). Researchers want to understand how this radiation affects the brain's white matter — the connections between brain regions — and whether changes on brain imaging can predict problems with memory, attention, or thinking abilities.
Some patients experience memory or thinking problems after brain radiation, but doctors currently have limited ways to predict who will be affected or how severe it might be. This study aims to identify brain imaging markers that could help doctors predict and potentially prevent these cognitive changes in future patients.
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You would complete brain MRI scans and cognitive testing (thinking and memory tests) at baseline and then at follow-up visits over one year. The study is observational, meaning researchers are tracking the effects of your routine radiation treatment rather than testing a new medication or intervention — they are simply monitoring your brain health and cognitive function over time to see how they change and whether imaging can predict thinking problems.
AI-generated summary from trial data · Aug 14, 2026 · Not medical advice
United States
Sponsor
UNC Lineberger Comprehensive Cancer Center
Enrollment target
~20 participants
Started
December 2019
Primary completion
May 2028
Age range
18 Years and older
Last updated on clinicaltrials.gov in August 2026.
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Central contact
Olivia Morton
University of North Carolina at Chapel Hill, Department of Radiation Oncology
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.