Plain-English translation of NCT04076449 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This is a 5-year study that follows patients who have a cavernous malformation in the brain. Cavernous malformations are abnormal blood vessel clusters that can sometimes cause seizures. The study will use special brain imaging scans and annual check-ups to track whether patients develop epilepsy, how brain structure changes over time, and whether surgery helps reduce seizures.
Doctors don't yet fully understand which patients with cavernous malformations will develop seizures, or how well surgery works for different people. This research aims to identify warning signs in brain imaging and blood samples that could help predict who is at risk and guide treatment decisions.
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You will have brain MRI scans and visit the research center annually for 5 years. At each visit, doctors will check for seizures using video recordings of brain activity (EEG), review your seizure diary, and collect blood samples. Some participants may choose to have surgery to remove the malformation during the study, and researchers will track how this affects seizures and brain health over time.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
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