Plain-English translation of NCT04101968 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Parkinson Disease research guide →This research study is looking at how a specific genetic mutation called GBA affects the brains of people with Parkinson's disease and people who carry the gene but don't have symptoms yet. Researchers will use advanced brain imaging scans and a simple typing test to see if they can spot early warning signs of brain changes linked to this genetic form of Parkinson's.
People with GBA mutations are at higher risk for Parkinson's disease and tend to develop thinking and memory problems faster than others with Parkinson's. By studying brain changes in people with this mutation—both those with and without Parkinson's symptoms—scientists hope to understand the disease better and find ways to detect it earlier.
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You would visit the research center for a clinical evaluation and a typing session, followed by brain imaging scans (an MRI and three PET scans using different tracers to look at brain chemicals). You'll also provide a blood sample so researchers can study the GBA enzyme. The study involves about 25 participants total—10 with Parkinson's disease and 15 who carry the gene but don't have symptoms yet.
AI-generated summary from trial data · Jun 28, 2026 · Not medical advice
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