Plain-English translation of NCT04106830 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This is an observational study that uses advanced MRI imaging techniques to monitor changes in the brain, spinal cord, and optic nerve in patients with neuroinflammatory diseases—conditions where the immune system mistakenly attacks nerve tissue. Researchers will compare imaging patterns between patients with different nerve inflammation conditions (such as multiple sclerosis, neuromyelitis optica spectrum disorder, and MOG antibody-associated disease) and healthy volunteers to better understand how these diseases damage nerve tissue and what causes long-term disability.
Current tests can detect some signs of nerve inflammation, but they don't show the full picture of how nerve tissue is being damaged in the brain and spinal cord—changes that appear to be key to understanding why some patients develop severe disability. This study uses newer, more detailed imaging techniques to reveal these microscopic and structural changes, which may help doctors better predict outcomes and develop better treatments.
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If you join this study, you will undergo advanced MRI brain and spine imaging scans to allow researchers to examine structural and functional changes in your nervous system. You will be compared with other patients who have similar conditions and with healthy volunteers to help identify patterns that explain how these diseases affect the brain and spinal cord. The study involves no medication or invasive procedures—only imaging scans and the sharing of your medical history.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
China
Sponsor
Beijing Tiantan Hospital
Enrollment target
~1,000 participants
Started
January 2019
Primary completion
December 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
16 Years – 75 Years
Last updated on clinicaltrials.gov in December 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Yaou Liu, PhD
Beijing Tiantan Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.