Plain-English translation of NCT04109131 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
The BrainStorm program is a large research study designed to help doctors better understand why cancer spreads to the brain and how to treat it more effectively. Researchers will collect tissue samples from your original tumor and spinal fluid samples to study the biology of brain metastases, and build a large database of patient information that will help guide future treatment development.
Currently, treating cancer that has spread to the brain remains challenging, and doctors don't fully understand why some patients develop brain metastases while others don't. This study aims to fill that knowledge gap by studying the unique characteristics of brain metastases compared to the original tumor, which could lead to new, more effective treatment strategies.
You likely qualify if…
You likely don't qualify if…
Your participation will happen in three time periods: before your brain metastases diagnosis (if you enroll early), at the time of diagnosis, and after diagnosis. You will be asked to provide tissue samples (which may already exist from previous biopsies) and undergo a lumbar puncture (spinal tap) to collect spinal fluid for analysis. You will also share your medical information and treatment history to help build a research database. The study is designed to follow you over time to track how your cancer evolves and responds to treatment.
AI-generated summary from trial data · Jul 12, 2026 · Not medical advice
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