Plain-English translation of NCT04113993 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Schizophrenia research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing bazedoxifene, a medication that works by affecting how the body uses estrogen, to see if it can help improve symptoms of schizophrenia in women. Researchers have found that estrogen may help reduce psychotic symptoms and improve thinking and memory problems. This study will compare the medication to a placebo (a dummy pill) to see if it's truly effective.
Current treatments for schizophrenia don't work well enough for everyone, and some people continue to struggle with symptoms and cognitive problems. This medication is being tested because it may work differently than older treatments and could offer safer, longer-term benefits for women with schizophrenia.
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You would take either the new medication or a placebo pill once daily for the duration of the study, while continuing your regular psychiatric medications and treatment. You would need to visit the study clinic for regular check-ups to monitor how you're doing, complete some thinking and memory tests, and have routine health screenings. The study involves 160 women, and researchers will compare symptom improvements between those taking the medication and those taking placebo.
AI-generated summary from trial data · Jun 14, 2026 · Not medical advice
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