Plain-English translation of NCT04114084 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Multiple Myeloma research guide →Researchers are investigating a potential connection between sleep apnea and multiple myeloma, a cancer of blood cells in the bone marrow. In preliminary laboratory studies, they found that when mice experienced repeated drops in oxygen (similar to what happens during sleep apnea), their bone marrow changed in ways that allowed cancer cells to grow more easily. This study will compare bone marrow samples from four groups of patients to understand whether this same mechanism might occur in people.
Doctors have noticed that obesity is a risk factor for both sleep apnea and multiple myeloma, but they don't fully understand why these two conditions are linked. This research aims to uncover whether the repeated drops in oxygen that occur during sleep apnea might create an environment in the bone marrow that allows myeloma to develop or worsen.
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If you qualify, you would participate as part of your standard medical care—specifically, when you are already scheduled for a bone marrow biopsy. Researchers would collect an extra sample during that biopsy to study whether sleep apnea has affected your bone marrow. You would also be asked about whether you have sleep apnea. The study involves no additional procedures beyond what you're already having done.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
United States
Sponsor
Michael Tomasson
Collaborators
Department of Health and Human Services
Enrollment target
~200 participants
Started
May 2019
Primary completion
May 2030
Age range
18 Years – 99 Years
Last updated on clinicaltrials.gov in November 2025.
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Central contact
Michael Tomasson, MD
University of Iowa
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