Plain-English translation of NCT04118387 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
Central sleep apnea is a condition where your breathing stops and starts during sleep, and standard treatments don't always work well enough. This study is testing whether combining a breathing mask device (called PAP) with different medications—acetazolamide, zolpidem, or buspirone—might work better together than any single treatment alone. The goal is to find the best combination approach to help veterans breathe more safely at night.
Many people with central sleep apnea don't get enough relief from current treatments. Researchers believe that combining treatments targeting different parts of how your body controls breathing during sleep may work better than using one treatment at a time.
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You would visit the research center multiple times to receive a breathing mask device and take one of the study medications by mouth. Researchers would monitor your sleep using specialized equipment and track how well you're breathing at night. The study involves testing your breathing patterns, following the treatment plan you're assigned to, and working closely with the research team to see if the combination approach improves your sleep apnea.
AI-generated summary from trial data · Aug 3, 2026 · Not medical advice
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