Plain-English translation of NCT04126018 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study compares three different ways of taking pictures of your heart to see which method is best at detecting valve disease. Researchers want to understand how well newer 3D ultrasound imaging works compared to traditional 2D ultrasound and cardiac MRI (a detailed magnetic scan). By comparing these methods, they hope to find the most accurate way to diagnose and measure how severe your valve problem is.
Doctors currently use different imaging methods to check heart valves, but they don't always agree on how severe the problem is. This study will help doctors figure out which imaging technique gives the most reliable information, so patients can get better diagnosis and treatment decisions.
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You will have heart imaging tests done at a baseline visit, including ultrasound and MRI scans. You'll complete questionnaires about your activity level and heart symptoms. A smaller group of participants (about 40) may also have an exercise stress MRI where you pedal a stationary bike inside the MRI machine. You'll return for follow-up visits and imaging 6 to 12 months later, and the research team will check your medical records over time to track your health outcomes.
AI-generated summary from trial data · Sep 5, 2026 · Not medical advice
United States
Sponsor
The Cleveland Clinic
Enrollment target
~200 participants
Started
August 2019
Primary completion
December 2027
Age range
18 Years – 90 Years
Last updated on clinicaltrials.gov in January 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Deborah Kwon, M. D.
The Cleveland Clinic
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.