Plain-English translation of NCT04130503 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether PAP (positive airway pressure) therapy — a breathing support machine that keeps your airway open while you sleep — can help improve recovery after an ischemic stroke in people who also have obstructive sleep apnea. Researchers want to know if starting this treatment early after a stroke, combined with healthy lifestyle education, helps people recover better and improve their quality of life.
Many people who have strokes also have undiagnosed sleep apnea, a condition where breathing repeatedly stops during sleep. This treatment gap may slow down recovery after stroke. Researchers want to test whether treating sleep apnea early with breathing support can give stroke patients a better chance at healing and regaining function.
You likely qualify if…
You likely don't qualify if…
If you qualify, you will be randomly assigned to either start breathing support therapy within one week of your stroke or one month after your stroke, while also receiving healthy lifestyle education focused on preventing future strokes. All participants will have check-in visits at 1 week, 1 month, and 3 months after joining the study, where researchers will assess your recovery, symptoms, and how well you're using the breathing support machine. You'll receive technical assistance and behavioral support to help you use the equipment and stick with the treatment plan throughout the study.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
United States
Sponsor
Yale University
Collaborators
Hartford HealthCare, National Institute of Nursing Research (NINR)
Enrollment target
~360 participants
Started
September 2019
Primary completion
October 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in September 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Radu Radulescu, MD
Yale University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.