Testing stronger tuberculosis meningitis treatment to improve survival

This trial is testing whether higher doses of tuberculosis drugs—particularly a stronger combination that includes linezolid—can save more lives in people with tuberculosis meningitis (a serious infection of the membranes around the brain). The study also tests whether adding aspirin to this treatment helps reduce brain damage from inflammation. Researchers are comparing this intensified approach to the standard tuberculosis treatment used worldwide.

Tuberculosis meningitis is one of the deadliest forms of tuberculosis, and current standard treatments don't work well enough—many people still die or suffer severe brain damage. This trial is investigating whether using stronger medications and doses can improve survival and reduce the devastating complications of this disease.