Tracking how scans change during advanced lung cancer treatment

Plain-English translation of NCT04151940 on ClinicalTrials.gov ↗ · Source last updated January 2026 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing whether special imaging scans called PET/CT can better track how advanced non-small cell lung cancer responds to treatment. Researchers want to understand what happens inside your body when you receive standard combined with —and sometimes radiation—to improve how doctors monitor your progress and adjust your care.

Doctors currently use standard imaging to see if lung cancer is shrinking, but these scans don't always show the full picture early on. This study aims to find out if more detailed imaging can detect changes in your cancer sooner and help doctors choose the best treatment plan for you.

Do you qualify?

You likely qualify if…

you have been newly diagnosed with stage IV (advanced) or recurrent non-small cell lung cancer that has not been treated with chemotherapy or immunotherapy before
you are planning to receive standard chemotherapy combined with immunotherapy as your treatment
you are at least 18 years old
your kidneys, liver, and blood cells are working well enough to safely receive the treatment
you are able to understand the study and commit to completing the imaging scans

You likely don't qualify if…

you have already been treated with immunotherapy drugs (like checkpoint inhibitors) for your advanced cancer
you have another active cancer requiring current treatment
you have an untreated active infection that could affect scan results
you have an autoimmune disease that currently requires systemic medication or steroids
you have active brain metastases (cancer spread to the brain) causing symptoms

What participation looks like

You would receive standard and as planned with your doctor—the study doesn't change your treatment. What's new is that you'll have special imaging scans (PET/CT) at key points: before you start treatment, shortly after your second round of , and if you receive radiation, before and one month after that as well. You'll also provide blood samples for the study. The imaging visits take place over several months alongside your regular cancer care.

AI-generated summary from trial data · Jun 3, 2026 · Not medical advice

Trial locations(1 site)

United States

Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington