Testing an immune therapy for small fiber nerve pain

This trial is testing intravenous immunoglobulin (IVIG)—a treatment made from donated antibodies—to see if it can reduce pain and improve nerve fiber health in people with autoimmune small fiber neuropathy. Small fiber neuropathy is a condition where the smallest nerves in your body become damaged, causing burning pain and other symptoms. The medication works by helping your immune system calm down and stop attacking your own nerves.

Right now, there's no proven standard treatment for autoimmune small fiber neuropathy, and doctors often turn to long-term steroids that come with serious side effects. Early evidence suggests this treatment may reduce pain and actually help nerve fibers heal, but it has never been properly tested in a controlled study to prove it really works.