Plain-English translation of NCT04157179 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Sickle Cell Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand how children's brains use oxygen, especially in children with sickle cell disease or those who have survived serious illnesses. The study uses special MRI brain scans to measure blood flow and oxygen use in the brain. This information could help doctors identify which children are at risk for brain injury and need treatment.
Children with sickle cell disease and those who have been critically ill are at higher risk for stroke and brain damage. Right now, doctors don't have good ways to predict which children will have these problems. This study hopes to find specific signs on brain scans that show when the brain is struggling and at risk for permanent injury.
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You will come to the hospital for MRI brain scans. During the scan, you'll lie still in the machine while researchers take detailed pictures of your brain and how it uses oxygen. For part of the scan, you may be asked to breathe air with a slightly higher level of carbon dioxide, which is delivered safely through a special device. The whole visit will take a few hours, and researchers may ask you to come back for follow-up scans over time.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
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