Plain-English translation of NCT04159662 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study uses a special brain imaging machine called an fMRI scanner to take detailed pictures of how your brain works while you think. Researchers want to better understand the thinking and memory problems that people with schizophrenia, schizoaffective disorder, or major depression sometimes experience. By comparing brain activity in people with these conditions to healthy volunteers, scientists hope to learn more about how these illnesses affect the brain.
Many people living with schizophrenia, schizoaffective disorder, or depression struggle with thinking, memory, and concentration problems that current treatments don't always fully address. This research aims to understand what's happening in the brain during these thinking difficulties so that doctors can eventually develop better treatments.
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You would visit the research center three times, each visit lasting about 2.5 hours. During the first two visits, you'll answer questions about your mental health history and complete some computer-based thinking tasks. At the third visit, you'll have a brain scan where you lie still in an fMRI machine (which uses magnetic fields, not radiation) and perform simple tasks like responding to words and pictures by pressing buttons. The whole process takes a few weeks spread across your three visits.
AI-generated summary from trial data · Jun 14, 2026 · Not medical advice
Canada
Sponsor
The Royal Ottawa Mental Health Centre
Enrollment target
~90 participants
Started
December 2019
Primary completion
October 2026
Age range
18 Years – 60 Years
Last updated on clinicaltrials.gov in March 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Synthia Guimond, PhD
Royal Ottawa Mental Health Centre
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.