Plain-English translation of NCT04174755 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a medication called semaglutide, when combined with lifestyle changes like diet and exercise, can help people living with HIV who struggle with obesity lose more weight. Semaglutide is a medication that helps reduce appetite and support weight loss. The study will compare people who receive the medication plus lifestyle support to people who receive lifestyle support alone.
People living with HIV often struggle with weight gain, which can affect their overall health and increase the risk of heart disease and diabetes. Researchers want to know if this medication could be a helpful tool—alongside diet and exercise—to help manage weight better in this population.
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If you join this study, you will be randomly assigned to one of two groups: one group receives the medication (semaglutide) along with diet and exercise counseling, and the other group receives diet and exercise counseling alone. You will need to visit the clinic regularly for check-ups, blood tests, and weight monitoring. The medication is given as a weekly injection that you can do yourself at home. Throughout the study, the research team will monitor your weight, blood sugar, cholesterol levels, and how well your HIV remains controlled.
AI-generated summary from trial data · Jul 7, 2026 · Not medical advice
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