Plain-English translation of NCT04191681 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This study is testing a medication called in people who have had a mechanical heart pump (also called a left ventricular assist device or LVAD) implanted to help their failing heart pump blood. The researchers want to see if this medication is safe and works well for these patients compared to the standard heart medications they usually receive.
After receiving a mechanical heart pump, patients need medications to help manage their blood pressure and support their heart function. This trial exists to find out whether this newer medication might be better or safer for this specific group of patients than the traditional treatments currently used.
You likely qualify if…
You likely don't qualify if…
If you join this study, you will either receive the new medication or continue on your usual heart medications. You'll have follow-up visits at 3 months, 6 months, and 12 months to check your blood pressure, blood tests, and how you're feeling. Your doctor will adjust the medication dose as needed to keep your blood pressure in a healthy range.
AI-generated summary from trial data · Jul 10, 2026 · Not medical advice
United States
Post-approval monitoring
Sponsor
The Cleveland Clinic
Enrollment target
~50 participants
Started
November 2019
Primary completion
March 2022
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in June 2021.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Jerry D Estep, MD
The Cleveland Clinic
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.