Stem cell transplant from a half-matched family donor for sickle cell disease

This trial is testing a new approach to stem cell transplantation for people with sickle cell disease who don't have a perfectly matched sibling donor. Instead of waiting for a fully matched donor, researchers are using stem cells from a half-matched family member (usually a parent) after specially treating those cells to reduce rejection risk. The goal is to see if this treatment can cure sickle cell disease with fewer serious side effects compared to traditional transplants.

Many people with severe sickle cell disease could benefit from a stem cell transplant, but only about 25% have a perfectly matched sibling donor. This trial exists to expand transplant options for the majority of patients who lack a matched family member, potentially offering them a cure they might not otherwise have access to.