Plain-English translation of NCT04214119 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study uses a small, easy-to-swallow capsule called EsophaCap to collect cell samples from your esophagus and stomach. Researchers will examine these samples to find genetic markers—like fingerprints in your cells—that can help doctors detect Barrett's esophagus, esophageal cancer, or gastric cancer much earlier than they can today. The goal is to develop a simple, non-invasive way to catch these serious conditions before they progress.
Early detection of Barrett's esophagus and esophageal or gastric cancer can save lives, but current detection methods are limited. This study aims to discover new genetic clues that could make screening easier and more accurate, potentially catching these conditions at stages when treatment is most effective.
You likely qualify if…
You likely don't qualify if…
If you qualify, you will swallow a small capsule (about the size of a large vitamin) during or around the time of your endoscopy. The capsule collects cells as it travels through your esophagus and stomach, then passes naturally out of your body. The entire process is quick and non-invasive—no surgery or sedation needed just for this capsule.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
United States
Collaborators
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Enrollment target
~2,500 participants
Started
January 2016
Primary completion
December 2028
Age range
18 Years and older
Last updated on clinicaltrials.gov in December 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Stephen J Meltzer, M.D.
Johns Hopkins University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.