Plain-English translation of NCT04214366 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing carbon ion radiation as a standalone treatment for adenoid cystic carcinoma, a rare slow-growing cancer of the head and neck region. Carbon ions are a type of radiation that can be aimed very precisely at tumors and may be more effective than standard radiation. The study hopes to show that using carbon ion radiation alone (rather than combined with other radiation) can improve the chances that the tumor won't come back.
Adenoid cystic carcinoma often comes back after treatment, and patients typically need radiation therapy more than once. While some hospitals combine carbon ions with standard radiation, there's no strong evidence from Europe about whether carbon ion radiation alone works better—or whether it could shorten treatment time and reduce side effects.
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You would receive carbon ion radiation therapy given in 22 doses over about 4 weeks as an outpatient (no hospital stay needed). After your treatment ends, you would be followed closely with check-ups and scans for 5 years to see how well the treatment works, whether the cancer comes back, and how you're doing overall. Doctors will also monitor you for any side effects and ask about your quality of life throughout the study.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
Germany