Plain-English translation of NCT04214587 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are studying lung tissue from patients who have received endobronchial lung valves (EBVs)—small silicone and metal devices placed inside the airways to help people with severe emphysema or COPD breathe better. This study aims to understand why the body's tissue sometimes reacts to these valves in ways that reduce how well they work over time, so doctors can make them more effective in the future.
While EBVs are an effective treatment for severe lung disease, their benefits don't always last because the body's natural healing response can cause scar tissue and inflammation around the device. By studying this tissue reaction, researchers hope to find ways to keep these life-improving implants working longer.
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If you need a repeat procedure to replace or remove your lung valves, researchers will collect small tissue samples during that procedure to study under a microscope. Some participants will also provide baseline health information at the start of the study. The study involves 150 patients total, with smaller groups providing tissue samples during necessary medical procedures.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
Netherlands
Enrollment target
~150 participants
Started
March 2021
Primary completion
March 2027
Last updated on clinicaltrials.gov in June 2024.
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Central contact
Dirk-Jan Slebos, MD PhD
UMC-Groningen/NL
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