Plain-English translation of NCT04215003 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Breast Cancer research guide →Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing combination of chemotherapy medications including Paclitaxel, Carboplatin, Herceptin, and Pertuzumab given before surgery for patients with locally advanced breast cancer. The research team will monitor how well this medication works and how safe it is. The goal is to shrink the tumor before surgery and improve outcomes.
Doctors want to understand the best way to give chemotherapy before surgery for breast cancer—specifically, whether different combinations and durations of treatment work better depending on the tumor's genetic characteristics. This medication approach aims to help more patients have successful surgery with better long-term results.
You will receive chemotherapy as an outpatient, typically given in cycles over several months before your planned surgery. The trial uses smart design that may adjust your treatment based on how you respond and your tumor's specific characteristics. You will have regular blood tests, scans, and check-ups to monitor how well the treatment is working and watch for side effects, then proceed to surgery once chemotherapy is complete.
AI-generated summary from trial data · Jun 24, 2026 · Not medical advice
China