Plain-English translation of NCT04219709 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand how a ketogenic (low-carbohydrate) diet might protect your brain when your blood sugar drops too low—a common and dangerous problem for people with type 1 diabetes. You'll either follow a low-carb diet or a standard diet for 12 weeks while researchers use MRI brain scans and insulin tests to see how your brain responds to low blood sugar. The goal is to learn whether this dietary approach can help your brain stay sharper and safer during hypoglycemia.
People with type 1 diabetes face serious risks when their blood sugar drops suddenly, including difficulty thinking clearly and dangerous seizures. Doctors want to know if changing what you eat might help your brain tolerate and respond better to these low-blood-sugar episodes.
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You'll be randomly assigned to eat either a low-carb diet or a standard diet, with meals provided to you for 12 weeks. During the study, you'll visit the research center for specialized tests where doctors will carefully lower your blood sugar using insulin while taking detailed MRI images of your brain. You'll also complete some simple thinking and memory tasks during these brain scans, and your blood will be tested to measure glucose, ketones, and hormones. The whole study lasts about 12 weeks, with the main testing visit taking several hours.
AI-generated summary from trial data · Jun 16, 2026 · Not medical advice
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