Plain-English translation of NCT04221997 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing , a medication commonly used to treat anxiety in children and teens. Researchers want to see if blood samples taken during treatment can predict which young people will respond well to the medication. You would either receive the real medication or a placebo (a pill with no medicine) for 12 weeks.
Anxiety disorders are common in young people, but not everyone responds the same way to treatment. This trial is trying to find biological markers in the blood that could help doctors predict who will benefit from this medication before treatment even begins, which could lead to faster, more personalized care.
You likely qualify if…
You likely don't qualify if…
You will visit the research clinic several times over 12 weeks. At each visit, researchers will take a blood sample and ask how you are feeling. You'll take either the real medication or a placebo daily at home, with doses adjusted as needed (ranging from 25–200 mg per day). A parent or guardian must help oversee your treatment and report on your progress. The study compares your blood samples over time to see if they can predict how well the treatment works for you.
AI-generated summary from trial data · Jul 2, 2026 · Not medical advice
United States
Phase
Post-approval monitoring
Sponsor
University of Cincinnati
Collaborators
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Enrollment target
~150 participants
Started
November 2019
Primary completion
September 2026
Age range
8 Years – 17 Years
Last updated on clinicaltrials.gov in November 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Heidi K Schroeder, BS
University of Cincinnati
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.