Plain-English translation of NCT04232566 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is investigating how inflammation in fat tissue and fat buildup in the liver are connected in people with obesity. The researchers want to understand how weight loss surgery—specifically gastric bypass—changes these patterns and how the liver responds. By studying these changes, scientists hope to better understand how obesity affects the liver and insulin resistance.
Many people with obesity develop fatty livers and chronic inflammation, which can lead to serious liver disease. This study exists to understand the connection between these problems and whether weight loss surgery can reverse or improve them—information that could help doctors better treat and prevent liver disease in people with obesity.
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You would undergo gastric bypass surgery as planned (standard care), and the study team would perform liver imaging before your surgery to assess any existing fibrosis or scarring. After your surgery, researchers would monitor how your liver fat and inflammation change as you lose weight, likely through follow-up visits with blood tests and imaging. The study helps track whether and how weight loss reverses liver changes associated with obesity.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States
Enrollment target
~60 participants
Started
February 2022
Primary completion
December 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
30 Years – 70 Years
Last updated on clinicaltrials.gov in January 2026.
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Central contact
Keegan M Stewart
Mayo Clinic
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