Plain-English translation of NCT04239079 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Parkinson Disease research guide →Researchers at Columbia University are studying whether Parkinson's disease and Alzheimer's disease involve the immune system attacking the brain. This study will analyze blood samples from people diagnosed with these conditions and from healthy volunteers to identify immune cells and proteins that may play a role in brain cell damage. Understanding these immune patterns could help scientists develop new treatments in the future.
For decades, doctors have noticed that inflammation is present in both Parkinson's disease and Alzheimer's disease, but they don't fully understand what triggers it or how it damages brain cells. Recent preliminary findings suggest the immune system may mistakenly recognize and attack the brain's own proteins. This study aims to confirm that connection and identify which specific immune responses are involved.
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If you enroll, you will be asked to donate a blood sample, which researchers will analyze to study your immune cells and genetics. Depending on which group you join (Parkinson's, Alzheimer's/mild cognitive impairment, or healthy control), you may also complete some brief memory or thinking tests. The study involves a one-time visit to Columbia University, and the blood draw takes only a few minutes.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
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