Plain-English translation of NCT04245748 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing two common antidepressants — and — to see which one works better for people with anxiety and depression together. If you don't improve enough after 11 weeks on one of these medications, the study adds a second medication to help. The goal is to figure out the best treatment plan for your specific situation.
Many people with anxiety and depression don't fully recover on one medication alone. Researchers want to find out which medication combinations work best so that doctors can help more patients feel better faster.
You likely qualify if…
You likely don't qualify if…
You will start by taking one of two medications ( or ) for 11 weeks in a blinded study, meaning neither you nor the researchers will know which one you're taking at first. At week 10, the study team will check how much you've improved. If you're doing well, your treatment continues as usual. If you're not improving enough, you'll enter phase two, where a second medication is added for 8 more weeks. Throughout the study, you'll have regular visits to check your progress and monitor how you're doing.
AI-generated summary from trial data · Jun 23, 2026 · Not medical advice
United States
Phase
Post-approval monitoring
Sponsor
University of Cincinnati
Enrollment target
~84 participants
Started
March 2020
Primary completion
July 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 50 Years
Last updated on clinicaltrials.gov in August 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Heidi K Schroeder, BS
University of Cincinnati
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.