Plain-English translation of NCT04271878 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial tests whether a breathing device that lets you inhale controlled levels of carbon dioxide can help reduce symptoms of POTS—a condition that causes your heart to race and makes you feel faint when you stand up. Researchers believe that increasing carbon dioxide levels in your blood may help your body maintain better blood pressure and heart rate stability during these episodes. The study involves using a mask connected to a specialized breathing system while lying down and then standing up.
Many people with POTS struggle with severe symptoms that limit their daily life, and current treatment options don't work for everyone. Early research in a small group of POTS patients showed that controlled carbon dioxide breathing helped reduce symptoms, but researchers need to test whether this works for a larger and more diverse group of patients.
You likely qualify if…
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You will visit the Autonomic Testing Lab at the University of Calgary where researchers will fit you with a face mask connected to a specialized breathing device. During the visit, you will lie down and then stand up while the device controls the carbon dioxide levels you breathe in, and researchers measure how your heart rate and blood pressure respond. The study will test you in different conditions to see if the controlled carbon dioxide breathing reduces your symptoms compared to standing up without the device.
AI-generated summary from trial data · Aug 24, 2026 · Not medical advice
Canada