Plain-English translation of NCT04274374 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This 24-week study is investigating whether removing gluten from your diet can help improve symptoms and quality of life for people with axial spondyloarthritis, an inflammatory condition that affects the spine. You'll be randomly assigned to eat either a gluten-free diet or a regular diet (with gluten) for 16 weeks, followed by an optional 8-week period where you can choose which diet to follow. The researchers will carefully measure how you're doing and track your diet throughout the study.
Some evidence suggests that certain foods, including gluten, may influence inflammation in the body. This trial aims to find out whether removing gluten from the diet could be a helpful, simple way to reduce symptoms and improve daily life for people with this type of arthritis.
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You will come in for an initial visit where a dietician will teach you how to follow your assigned diet (either gluten-free or regular). Over 24 weeks, you'll eat your assigned diet and have check-in visits with the dietician at weeks 2, 16, and 24, where you'll answer questions about what you've been eating. For the first 16 weeks, your diet is fixed, but then for the final 8 weeks, you can choose to continue or stop your assigned diet based on how you're feeling. Throughout the study, you'll complete online food questionnaires to help researchers track your eating habits and measure any changes in your symptoms and quality of life.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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