Plain-English translation of NCT04275518 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a new medication called to see if it can help people whose blood cancer has come back or stopped responding to previous treatments. Researchers will first test the medication by itself at different doses to find the right amount, then test it combined with other chemotherapy drugs. The goal is to understand how safe the medication is and how well it works for people with these specific types of blood cancer.
Acute myeloid leukemia and myelodysplastic syndrome can be very difficult to treat, especially when they return or stop responding to standard therapies. Doctors and researchers are looking for new treatment options that might help patients in this difficult situation have better outcomes.
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The study happens in stages. First, researchers will give small groups of patients increasing doses of the medication by itself over 7 days every 28 days to find the safest and most effective dose. Once that is determined, other patients will receive the medication combined with standard chemotherapy drugs at increasing doses. Throughout the trial, you will have regular clinic visits to check your blood counts, organ function, and overall health, and doctors will watch carefully for any side effects.
AI-generated summary from trial data · Jul 15, 2026 · Not medical advice
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