Plain-English translation of NCT04276857 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a two-step approach for locally advanced pancreatic cancer. First, you would receive combination chemotherapy (multiple cancer-fighting drugs given together). If your cancer responds well to the chemotherapy, you would then receive irreversible electroporation (IRE), which is a procedure that uses electrical pulses to destroy cancer cells. The goal is to see if this combination approach can help more people survive longer.
Pancreatic cancer is very serious, and people with locally advanced disease (cancer that has grown into nearby tissues but hasn't spread to distant organs) currently have very few good treatment options and a poor outlook. Doctors don't yet know the best way to treat this stage of pancreatic cancer, so this trial is exploring whether adding the electric pulse procedure to chemotherapy could improve survival.
You likely qualify if…
You likely don't qualify if…
You would start by receiving combination chemotherapy, which involves multiple anti-cancer drugs given over several treatment cycles. Your doctors will monitor how well your cancer responds using imaging scans and blood tests. If your cancer shrinks or stops growing, you would then be eligible to receive the irreversible electroporation procedure, which uses electrical pulses to target and destroy the remaining cancer cells. The trial involves regular clinic visits for treatment and monitoring.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
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