Plain-English translation of NCT04310098 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study is building a registry—a database of information—to help doctors better understand CADASIL, a rare genetic condition that damages small blood vessels in the brain. Researchers will follow people who have CADASIL, people who carry the genetic mutation but don't have symptoms yet, their relatives, and healthy volunteers over time to see how the disease develops and progresses. The goal is to learn how to identify the disease earlier and manage it better.
Currently, doctors don't fully understand how CADASIL progresses in different people or how to predict who will develop symptoms and when. By collecting information from many patients and families over time, researchers hope to improve how the condition is diagnosed and treated.
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You would join a long-term registry study at one of several medical centers. Participation typically involves sharing your medical records, undergoing clinical evaluations and brain imaging (such as MRI), providing blood samples for genetic testing, and having follow-up visits over time. The study does not involve taking a new medication—instead, researchers observe and document how CADASIL naturally progresses in you and your family members to better understand the disease.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
China
Sponsor
Bin Cai
Enrollment target
~1,000 participants
Started
March 2020
Primary completion
March 2039
Age range
18 Years – 85 Years
Last updated on clinicaltrials.gov in September 2023.
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Central contact
Lin Yi, PhD
Bin Cai
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