Plain-English translation of NCT04310644 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This is a research registry study that brings together patients with several related autonomic nervous system disorders—including postural orthostatic tachycardia syndrome (POTS), autoimmune autonomic neuropathy, small fiber neuropathy, and Ehlers-Danlos syndrome. Researchers want to better understand how these conditions develop and how to diagnose them more accurately by comparing specialized test results between patients and healthy volunteers.
Many people with these autonomic conditions struggle with confusing or delayed diagnoses because doctors don't yet fully understand what's going wrong in their nervous systems. This study aims to fill that gap by carefully studying how the autonomic nervous system fails in different ways, which could lead to better and faster diagnosis for future patients.
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You will visit the research center for baseline testing, which includes blood work, questionnaires about your health and symptoms, attention tests, heart and blood pressure monitoring during position changes (tilt table test and standing test), sweat function assessment, and nerve fiber testing through skin examination. Follow-up visits will be offered so researchers can track how your condition changes over time. Most of these tests are performed as part of routine clinical care.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
Germany
Sponsor
RWTH Aachen University
Collaborators
DLR German Aerospace Center
Enrollment target
~200 participants
Started
September 2019
Primary completion
September 2028
Age range
18 Years – 80 Years
Last updated on clinicaltrials.gov in February 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Andrea Maier, physician
University Hospital, Aachen
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.