Plain-English translation of NCT04312399 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand how hormone replacement therapy—specifically progesterone plus uterogestan given by mouth, or estrogel plus uterogestan applied to the skin—might affect brain health and dementia risk in postmenopausal women. This study will track changes in blood markers related to brain function over 12 months to see if the medication influences how the brain processes proteins linked to Alzheimer's disease.
Doctors don't yet know whether hormone therapy helps, harms, or has no effect on a woman's risk of developing dementia after menopause. This medication is already used to treat hot flashes and other menopause symptoms, but its connection to brain health remains unclear.
You likely qualify if…
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If you join, you'll have three study visits over one year: one before you start hormone therapy, one at 6 months, and one at 12 months. At each visit, you'll have blood drawn for analysis and complete brief questionnaires about sleep quality, mood, and other symptoms. At your first visit, you'll also take a short memory test to make sure you don't have signs of dementia. The whole process takes about one year, and the blood work takes only a few minutes each time.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
Belgium
University Hospital, Ghent
Enrollment target
~600 participants
Started
April 2018
Primary completion
December 2027
Age range
40 Years – 65 Years
Sex
Female only
Last updated on clinicaltrials.gov in January 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Eline Meireson, Msc
University Hospital, Ghent
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.