Plain-English translation of NCT04328337 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
Researchers want to understand how obesity might change the way your brain uses glucose (blood sugar). In this part of the study, healthy adults will receive either Intralipid—a fatty liquid given through an IV—or salt water (placebo), and then have their brain scanned to see how it processes glucose. This helps scientists learn whether temporary changes in blood fat levels affect brain function.
People with obesity often have changes in how their bodies handle sugar and fats. Scientists don't fully understand whether these changes affect how the brain uses glucose, which is important for brain health. This study will help answer that question so doctors can better understand and treat obesity-related health problems.
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You would visit the research center for a brain imaging scan. Before and during your second scan, you'll receive a 12-hour IV infusion of either the fatty acid medication or salt water (you won't know which one). The study involves lying still in an MRI machine while researchers measure how your brain processes glucose. The entire process takes about one day, including setup, the infusion, and the scan.
AI-generated summary from trial data · Jul 1, 2026 · Not medical advice
United States