Plain-English translation of NCT04339374 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a new imaging device called photoacoustic ultrasound that combines ultrasound with light-based imaging to get better pictures of rectal cancer. The goal is to help doctors more accurately determine whether cancer has completely responded to chemotherapy and radiation, so they can avoid unnecessary surgery when the cancer is truly gone.
Right now, doctors have difficulty knowing for certain whether rectal cancer has completely disappeared after chemotherapy and radiation. This uncertainty sometimes leads to surgery that may not be needed, which carries risks and complications. This new imaging tool aims to give doctors a clearer picture so they can confidently spare some patients from surgery without missing any remaining cancer.
You likely qualify if…
You likely don't qualify if…
If you qualify, you would undergo a 20-minute imaging procedure with the new photoacoustic ultrasound probe while under anesthesia before your scheduled rectal cancer surgery. The surgeon performing your operation would use this special probe to create detailed images of your tumor. After the imaging is complete, you would proceed with your standard surgical care. There are no additional follow-up visits required beyond your normal cancer care.
AI-generated summary from trial data · Aug 11, 2026 · Not medical advice
United States