Plain-English translation of NCT04356326 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether acetyl salicylic acid (aspirin) at a dose of 150 mg per day can help prevent serious pregnancy complications in women who have chronic high blood pressure. About 45% of pregnant women with chronic hypertension develop problems like preeclampsia, placental abruption, or slow fetal growth. Researchers want to see if this medication, taken early in pregnancy, can reduce these risks.
Even though major health organizations like the American College of Obstetrics and Gynecology recommend low-dose aspirin for pregnant women with chronic high blood pressure, there isn't enough solid scientific evidence to prove it actually works for this group. This study aims to fill that gap and provide clear answers about whether this treatment truly helps prevent pregnancy complications.
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You would take either a 150 mg aspirin tablet or a placebo (a pill with no active ingredient) once daily in the evening, starting in your second trimester and continuing through your pregnancy. You'll be randomly assigned to receive either the medication or placebo, and neither you nor your doctors will know which one you're taking. Throughout your pregnancy, you'll have regular clinic visits to monitor your blood pressure, urine protein levels, and baby's growth, with close attention to any signs of complications.
AI-generated summary from trial data · Aug 22, 2026 · Not medical advice
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