Plain-English translation of NCT04368039 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This is a pilot study testing whether normobaric oxygen therapy—breathing enriched oxygen through a nasal tube while you sleep—might help reduce symptoms of first-episode psychosis. Researchers believe that psychosis may involve problems with how the brain's energy-producing cells (mitochondria) function, and that extra oxygen might help restore normal brain activity in key regions.
People with psychosis often have reduced activity in certain brain regions, which may be linked to cells not getting enough oxygen. This treatment hasn't been tested for psychosis before, so researchers want to see if this simple, safe approach might offer a new way to help symptoms improve.
You likely qualify if…
You likely don't qualify if…
You'll come in for an initial visit, then use a nasal tube connected to an oxygen machine for 4 weeks while you sleep at night. Half of participants will receive enriched oxygen, and half will receive regular air (you won't know which). After 4 weeks, everyone receives the enriched oxygen treatment for another 4 weeks. You'll have check-in visits at 4 weeks and 8 weeks to see how you're doing.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
United States
Nicholas Breitborde
Enrollment target
~20 participants
Started
December 2019
Primary completion
December 2026
Age range
15 Years – 35 Years
Last updated on clinicaltrials.gov in February 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Nicholas Breitborde, PhD
Nicholas Breitborde
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.