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Eye imaging scans to detect memory and thinking disorders

Plain-English translation of NCT04389437 on ClinicalTrials.gov ↗ · Source last updated September 2025 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

Researchers are studying whether advanced eye imaging techniques can detect early signs of memory and thinking disorders like Alzheimer's disease and Parkinson's dementia. The study uses two specialized eye scans — called optical coherence tomography angiography (OCT-A) and adaptive optics — to look at the tiny blood vessels and structure of the retina (back of the eye). These scans are completely non-invasive and painless, and researchers believe they may reveal patterns that could help identify these conditions earlier.

Recent studies suggest that people with memory disorders often have changes in the blood vessels at the back of their eyes, but no one has thoroughly studied this using the newest imaging technology. If this treatment can reliably detect these eye changes, it could become a simple, quick way to help doctors identify memory disorders in their earliest stages.

Do you qualify?

You likely qualify if…

you are coming to a memory clinic because you or a doctor is concerned about your memory
you are accompanying someone to a memory clinic visit
you have been diagnosed with Alzheimer's disease, Parkinson's dementia, Lewy body disease, or another memory disorder
you score at least 26 out of 30 on standard thinking and memory tests (if you do not have memory complaints)
you are at least 18 years old

You likely don't qualify if…

you are pregnant or breastfeeding
you have a history of stroke, brain tumor, or multiple sclerosis
you have a history of eye disease or significant vision problems requiring strong corrective lenses
you have taken certain medications like ethambutol for more than 2 months or antimalarial drugs for more than 2 years
you cannot have an MRI scan for medical reasons

What participation looks like

If you qualify, you will have your eyes scanned using two advanced imaging machines — both are quick, painless, and non-invasive. The scans take pictures of the tiny blood vessels and structure at the back of your eye. You may also have standard memory and thinking tests and possibly an MRI scan of your brain. The entire visit typically takes a few hours, and you should expect one main visit, though researchers may ask for follow-up information.

AI-generated summary from trial data · Jun 10, 2026 · Not medical advice

Eye imaging scans to detect memory and thinking disorders

What is this trial?

Do you qualify?

What participation looks like

Trial locations