Testing a new cancer drug alone and with other treatments

Plain-English translation of NCT04389632 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated July 2026 · How we translate trials

Read our Carcinoma, Non-Small Cell Lung research guide →

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

What is this trial?

This trial is testing a new cancer medication called to see if it is safe and works well for people with advanced solid tumors. The study will test the medication by itself in some patients, and combined with other cancer drugs (like , , or ) in others. Researchers will carefully monitor patients to understand how well the treatment works and what side effects it may cause.

Many patients with advanced cancers need new treatment options because their tumors have stopped responding to standard therapies. This medication uses a new approach to fight cancer, and this trial will determine whether it could become a helpful option for people with several different types of advanced cancer.

Do you qualify?

You likely qualify if…

you have been diagnosed with an advanced solid tumor (such as lung, head and neck, breast, esophageal, pancreatic, bladder, cervical, stomach, or ovarian cancer) that has been confirmed by biopsy
your cancer has either progressed despite previous treatment, or you cannot tolerate standard treatments
you have not received previous systemic treatment for advanced cancer (for Parts C and D)
you are in good enough overall health to tolerate the study treatment, with an Eastern Cooperative Oncology Group Performance Status of 0 or 1
you have measurable disease that can be assessed by imaging scans
you are willing to provide a tumor biopsy sample before and during the trial

You likely don't qualify if…

you have had another cancer diagnosed within the past 3 years (except for certain low-risk cancers)
you have active cancer in your brain, or previously treated brain cancer that is not stable
you have untreated brain metastases larger than 1 cm (except in Part D under specific circumstances)
you are currently taking corticosteroids for symptoms related to brain metastases

What participation looks like

Depending on which part of the trial you join, you will either receive the new medication alone or in combination with other cancer drugs. You will visit the clinic regularly for treatment infusions and monitoring, including blood tests and imaging scans to assess how well the treatment is working. You will also be asked to undergo a tumor biopsy before treatment starts and possibly during treatment to help researchers understand how the medication affects your cancer cells.

AI-generated summary from trial data · Jul 8, 2026 · Not medical advice

Testing a new cancer drug alone and with other treatments

What is this trial?

Do you qualify?

What participation looks like

Trial locations(158 sites)