Plain-English translation of NCT04406714 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Colorectal cancer research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial tested whether mailing FIT (fecal immunochemical test) screening kits directly to people's homes was an effective way to increase colorectal cancer screening in underserved communities. The study involved nearly 4,300 people ages 45–75 who had never been screened or hadn't been screened recently. Some participants received mailed FIT kits, while others received usual care, and researchers measured whether the mailing approach helped more people get screened and whether it was cost-effective.
Colorectal cancer is preventable when caught early, but many people—especially those in vulnerable populations—don't get screened regularly because of barriers like transportation, cost, or lack of awareness. This trial aimed to test whether making screening easier by mailing tests directly to homes could help reach more people and reduce colorectal cancer burden in communities that need it most.
Participants were randomly assigned to either receive mailed FIT screening kits at home or receive usual care (standard screening offered through their clinic). Those who received the mailing kits were sent one test per year for up to two years, which they could complete at home and mail back. If a test came back abnormal, some participants also received help from patient navigators who called to help arrange a follow-up colonoscopy. The trial took place over approximately two years.
AI-generated summary from trial data · Oct 5, 2026 · Not medical advice
United States