Plain-English translation of NCT04421248 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
Researchers want to understand whether , a common medication prescribed for ADHD, changes specific patterns of brain activity that may be different in children with ADHD. This study uses a special brain scanning technique called Transcranial Magnetic Stimulation (TMS) to measure two specific brain activity patterns before and after taking the medication. If successful, these brain measurements could one day help doctors choose the best treatment for each child's unique type of ADHD.
Right now, doctors diagnose ADHD and decide on treatment based mostly on observing behavior and asking questions. This trial is trying to find objective brain-based measurements that could make diagnosis and treatment decisions more precise and personalized for each child.
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You would visit the research clinic three times over a few weeks. At the first visit, the team will explain the study and answer your questions. At visits two and three, you'll receive either the medication or a placebo (a pill with no active ingredient), and researchers will use the TMS machine to measure your brain activity—a painless procedure that involves placing a special coil on your scalp. The order of medication and placebo will be randomized, meaning you won't know which one you're getting each time.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
United States