Plain-English translation of NCT04421846 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
The COLETTE study is collecting biological samples and medical information from patients with severe, hard-to-treat seizures — especially those caused by the immune system attacking the brain. Researchers will study blood, spinal fluid, and sometimes brain tissue to understand why these seizures happen and develop better ways to protect the brain and control the condition.
Severe seizures and immune-related brain inflammation can cause permanent brain damage and serious long-term disability. Doctors need better ways to understand what triggers these conditions and stop them early. This study aims to discover new targets for treatment and ways to protect the brain.
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If you join this study, you will donate blood samples and possibly spinal fluid (collected by a needle in the lower back). Researchers will also review your medical imaging scans (MRI, CT) and brain electrical recordings if available. For some participants, researchers may collect brain tissue samples after death if you choose to donate your brain to science. The study has no set end date — it is an ongoing collection to build a research database.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
France