Plain-English translation of NCT04437498 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our PTSD research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a treatment called non-invasive vagal nerve stimulation (nVNS) in veterans who have both mild traumatic brain injury and PTSD. The treatment works by gently stimulating a nerve in your neck that helps regulate your body's stress response. Researchers want to see if this treatment can improve memory, reduce physical stress reactions, and help with PTSD and pain symptoms.
Many veterans experience both brain injury and PTSD together, and these conditions can make it hard to remember things and manage stress. This medication offers a non-surgical option that may help the brain heal and calm the nervous system without the side effects of some traditional medications.
You likely qualify if…
You likely don't qualify if…
You would visit the research clinic several times over a four-day period for memory and stress tests, during which the nerve stimulation device would be applied to your neck. The researchers will measure how your body responds using blood tests, heart rate monitors, and brain imaging scans. You would then continue the treatment twice daily at home for three months, with follow-up visits to check how you're doing and whether your PTSD and pain symptoms have improved.
AI-generated summary from trial data · Jun 17, 2026 · Not medical advice
United States