Plain-English translation of NCT04438213 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Heart Failure research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
Researchers at Yale University are testing a medication called to see if it can help people with heart failure manage the extra fluid that builds up in their bodies. The study compares this new treatment to a commonly used diuretic medication () and to a placebo (an inactive pill). They want to understand how this medication affects body fluid balance and kidney function in heart failure patients, whether or not they have diabetes.
Heart failure often causes dangerous fluid buildup in the body, and current treatments don't work equally well for everyone. Researchers hope this medication might offer a new way to help remove excess fluid and potentially protect the kidneys while doing so.
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You would be randomly assigned to take either the new medication, the standard diuretic, or a placebo pill for 6 weeks. During this time, you would have study visits where researchers measure your body's fluid levels, collect blood and urine samples, and give your body a salt challenge to see how it responds. You'll need to carefully collect urine samples and follow study procedures closely throughout the 6-week period.
AI-generated summary from trial data · Jun 25, 2026 · Not medical advice
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