Recruiting

Testing plasma from recovered COVID patients to treat hospitalized adults

Plain-English translation of NCT04442191 on ClinicalTrials.gov ↗ · Source last updated June 2020 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing —a blood product collected from people who have recovered from COVID-19 and developed antibodies against the virus. The study will give some hospitalized COVID-19 patients an infusion of this plasma to see if it helps them recover faster and more completely. Researchers will compare outcomes in patients who receive the plasma against those who receive a placebo (a harmless substitute) to understand whether this treatment truly makes a difference.

Early in the COVID-19 pandemic, doctors observed that plasma from recovered patients might contain protective antibodies that could help fight the virus in severely ill patients. This trial aims to rigorously test whether this treatment actually works and is safe for hospitalized adults with moderate COVID-19.

Do you qualify?

You likely qualify if…

you are at least 40 years old
you have tested positive for COVID-19 within the past 72 hours
you have COVID-19 symptoms such as fever, cough, shortness of breath, or rapid breathing
you need supplemental oxygen (1–5 liters per minute by nasal tube) to keep your oxygen levels above 92%
you are willing to receive only supportive care and no other experimental COVID-19 treatments during the study

You likely don't qualify if…

you have a known Immunoglobulin A deficiency (a rare immune condition that increases risk of severe reaction to plasma)
you are currently on a mechanical ventilator
you have had a severe reaction to a blood transfusion in the past
you have a chronic lung condition or moderate-to-severe asthma or emphysema that already requires supplemental oxygen
you are pregnant or breastfeeding

What participation looks like

If you enroll, you will have a screening visit where you answer questions about your symptoms, undergo a brief physical exam, and have blood drawn for testing and storage. You will then receive a single infusion of either or placebo, and the study team will monitor your vital signs, oxygen levels, and overall recovery. You will have a follow-up phone call 28 days after enrollment to check on your health status.

AI-generated summary from trial data · Jun 18, 2026 · Not medical advice

Testing plasma from recovered COVID patients to treat hospitalized adults

What is this trial?

Do you qualify?

What participation looks like

Trial locations