Plain-English translation of NCT04446832 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial is studying how well vaccines work in people waiting for a liver transplant and after they receive one. Because liver disease weakens the immune system, doctors worry that standard vaccines may not protect these patients as well as they protect healthy people. This study will measure whether the recommended vaccines actually provide good protection 6 months after transplant.
People with serious liver disease are at higher risk for severe infections from preventable diseases. While doctors recommend vaccines for transplant candidates, there is very little real-world evidence showing whether these vaccines actually work well in this population or how long the protection lasts after transplant.
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You would receive the vaccines your doctor recommends as part of standard pre-transplant care. The study team would then check your blood at different time points to measure whether your body developed protection against the diseases you were vaccinated for — both before your transplant and again 6 months after. You would also share information about how well you tolerated the vaccines and any side effects you experienced.
AI-generated summary from trial data · Jun 21, 2026 · Not medical advice
France
Enrollment target
~100 participants
Started
July 2020
Primary completion
July 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in November 2023.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Florent VALOUR, Dr
Hospices Civils de Lyon
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.