Plain-English translation of NCT04447352 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This study is testing a combination approach for people with advanced stomach cancer that can be surgically removed. All participants first receive several cycles of standard chemotherapy (FLOT), then surgery. Half will receive only additional standard chemotherapy after surgery, while the other half will receive heated chemotherapy applied directly inside the abdomen during surgery, plus additional standard chemotherapy afterward. The goal is to see if this heated chemotherapy approach improves survival and keeps cancer from coming back.
Stomach cancer, especially the diffuse type, is aggressive and often returns after surgery even with standard chemotherapy. Researchers are testing whether delivering chemotherapy directly to the area where cancer is most likely to return—heated to help it work better—can improve outcomes for patients.
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If you join this trial, you will already have completed your pre-operative chemotherapy before enrolling. You'll be randomly assigned to one of two groups: one group receives standard post-operative chemotherapy after surgery, and the other receives the same chemotherapy plus a special heated chemotherapy treatment applied directly into your abdomen during the surgery itself. After surgery, you'll receive four more cycles of chemotherapy over several weeks. You'll have regular follow-up visits to monitor how well the treatment is working and watch for any side effects.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
Germany